Management of Chemotherapy-Induced Nausea and Vomiting.
Loading...
Date
2010-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Context: Chemotherapy-induced nausea and vomiting (CINV) is a significant problem in the treatment of children with
cancer. The last decade has seen a variety of newer antiemetics being evaluated for CINV; their efficacy and side-effects
need to be assessed in children. This article attempts to highlight this revised management of CINV.
Evidence acquisition: Online search; journals. Search period: 6 months.
Results: Newer drugs (aprepitant, fosapritant and newer 5HT3 antagonists) have been found to be effective in CINV: both
acute and delayed phases. Most of the available literature is, however, based on adult oncology patients, with a few trials
on adolescent patients.
Conclusion: Every child receiving treatment for cancer should be evaluated for possible CINV. Their treatment should
take into account the emetogenic potential of the chemotherapeutic drugs. Newer antiemetic drugs have good efficacy
and can be tried in pediatric patients, especially in children > 11 years of age.
Description
Keywords
Antiemetic, Cancer, Chemotherapy, Nausea, Vomiting
Citation
Dewan Pooja, Singhal Swati, Harit Deepika. Management of Chemotherapy-Induced Nausea and Vomiting. Indian Pediatrics. 2010 Feb; 47(2): 149-155.