Lipid Peroxidation in Preeclampsia.
Loading...
Date
2015-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Hypertension in pregnancy is a leading cause of both maternal and fetal mortality and morbidity.
Preeclampsia is characterised by hypertension and proteinuria. Lipid peroxidation is an important factor in the
pathophysiology of Preeclampsia. The present study was undertaken to determine Serum Malondialdehyde (MDA)
levels , a product of lipid peroxidation , in clinically diagnosed Preeclamptic women(n=30) and the values were
compared with that of Normotensive pregnant women (n=30) aged between 18-30yrs. All of them were in their
third trimester and were primigravida. Serum MDA was estimated by TBARS (thiobarbituric acid reactive
substances) method. We observed that Serum MDA levels were significantly increased in Preeclamptic women (p
<0.000) as compared to that of Normotensive pregnant women . Increased levels of lipid peroxiation product -
MDA may contribute to the pathophysiology of Preeclampsia.
Description
Keywords
MDA, Preeclampsia, Oxidative Stress
Citation
Krishna T Sharmila, Rajeswari D Raja, Rao E Venkat, Deepthi S K, Naidu J N. Lipid Peroxidation in Preeclampsia. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Jan-Mar; 6(1): 94-96.