Hepatoprotective Activity of a Unani Polyherbal Formulation “Kabideen” in CCl4 Induced Liver Toxicity in Rats.
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Date
2015-01
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Abstract
Objective: To evaluate the hepatoprotective effect of Kabideen Syrup in rats treated with carbon tetrachloride.
Methods: In hepatotoxic rats, liver damage was studied by assessing parameters such as aspartate aminotransferase
(AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, total proteins, and cholesterol and
lipid peroxidation. Histopathological study of the liver in experimental animals was also undertaken.
Results: Hepatic damage as evidenced by a rise in the levels of AST, ALT, ALP, bilirubin cholesterol and
Malondialdehyde (MDA) and decreased level of total protein in serum. Liver showed a tendency to attain near
normalcy in animals co-administered with kabideen (50 ml/kg) significantly reduced the serum alanine
aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and cholesterol levels and
increased the total protein levels when compared to the CCl4 group. The histopathological findings showed a
significant difference between the Kabideen (50ml/kg) and CCL4 treated groups.
Conclusion: The study substantiates the hepatoprotective potential of Kabideen.
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Keywords
Carbon tetrachloride, marker enzymes, cholesterol, total protein
Citation
Zameer Mahim, Rauf Abdur, Qasmi Iqbal Ahmad. Hepatoprotective Activity of a Unani Polyherbal Formulation “Kabideen” in CCl4 Induced Liver Toxicity in Rats. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Jan-Mar; 6(1): 8-16.