Correlation of Coronary Angiographic Severity with Carotid intima Media Thickness and Flow mediated dilatation of brachial Artery in Patients with Ischemic Heart Disease.
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Date
2013
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Abstract
Background: Ischemic Heart Disease which encompasses Acute Coronary Syndrome and Chronic Stable
Angina is the most common cause of worldwide mortality and morbidity. Carotid intima media thickness
(CIMT) is a non-invasive ultrasonographic technique to image the carotid arteries which measures the
thickness of the intima and media of these vessels. It is a marker of atherosclerotic process. Flow mediated
dilatation (FMD) is a marker of endothelial function of arteries. Ischemic heart disease can be predicted
long before its actual occurrence by observing these two phenomenons.
Methods: This cross sectional study done in the Department of Cardiology, Dhaka Medical College Hospital
during the period of Oct 2010- Sept 2011.We enrolled 102 patients admitted with IHD by purposive sampling.
We assessed FMD of brachial artery, CIMT by vascular duplex. Coronary artery disease severity was
assessed by vessel score, stenosis score and extent score from angiography.
Results:The mean (±SD) age of the patients was 50.9(±11.3) years. The male- female ratio was 5:1. CIMT
has significant negative correlation with FMD (r=-.407, p=<.001). Flow mediated dilatation of brachial
artery has weak but significant negative co-relation with vessel score(r=-.609, p=<.001), stenosis score(r=-
.493, p=<.001) and extent score (r=-.477, p=<.001). However, carotid intima media thickness has weak but
positive correlation with vessel score (r=.447, p=<.001), stenosis score (r=.417, p=<.001) and extent
score(r=.412, p=<.001).
Conclusion: The present study concludes CIMT has significant negative correlation with flow mediated
dilatation of brachial artery. FMD has weak but significant negative co-relation and CIMT has weak but
positive correlation with vessel score, stenosis score and extent score of coronary arteries.
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Keywords
Carotid intima media thickness (CIMT), Flow mediated dilatation (FMD), Coronary angiography
Citation
Mahabub S M E, Islam A E M M, Sabah K M N, Chowdhury A W, Ghiasuddin M, Khan H I L R, Ali M S. Correlation of Coronary Angiographic Severity with Carotid intima Media Thickness and Flow mediated dilatation of brachial Artery in Patients with Ischemic Heart Disease. Cardiovascular Journal. 2013; 5(2): 165-172.