Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats.
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Date
2014-10
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Abstract
Peptic ulcer disease is a common condition of present day life, and its incidence is markedly increasing.
The available drugs for the treatment are associated with adverse effects. Hence, there is a need for newer and better
treatment for the same. Objectives: To evaluate the anti-ulcer activity of ethanolic extract of Vitis Vinifera (seed) by
Water Immersion stress induced gastric ulcer model in Wistar albino rats using two doses (100, 200mg/kg body weight.)
Methods: The antiulcer activity was assessed by estimating gastric volume, pH, free and total acidity; ulcer number and
its inhibition, gastric lesion, ulcer severity and ulcer index; and comparing it with the control groups.
Results: The present study revealed that grape seed extract of 100mg/kg and 200mg/kg showed a significant (p<0.05)
reduction in the gastric volume, ulcer number, gastric lesion and severity. The ulcer index was 45.33 and 36.66 for 100
and 200mg/kg respectively. Ulcer inhibition for 100 and 200 mg/kg group was 32.79% and 44.86% when compared with
the control group. Ulcer protection with 100 and 200mg/kg was 29.21% and 39.82% when compared with the control
group. Conclusion: This present study indicates that Vitis vinifera seed extract have potential anti-ulcer activity in the
model tested.
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Keywords
Vitis vinifera, Anti-ulcer, Stress ulcer, Free acidity, Total acidity, Ulcer index
Citation
Ingale Anand M, Rajendran Vijaya, Pinnelli Venkata BharatKumar. Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats. International Journal of Applied Biology and Pharmaceutical Technology. 2014 Oct-Dec; 5(4): 107-112.