The Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 and Cardiovascular Disease.
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2011
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Abstract
Lectin-like oxidized LDL receptor-1 (LOX-1), a lectin-like 50-kD receptor for oxidized low-density
lipoproteins (ox-LDL), is present primarily on endothelial cells. Oxidatively modified low-density
lipoprotein (oxLDL) is implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is
the initial change in the vascular wall that induces morphological changes for atheroma-formation.
LOX-1 was identified as the receptor for oxLDL that was thought to be a major cause of endothelial
dysfunction. LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but
also to atherosclerotic-plaque formation, hypertension, myocardial infarction and intimal thickening
after balloon injury. Studies with transgenic and knockout mouse models have elucidated in part
the role of LOX-1 in the pathogenesis of atherosclerosis and cardiac remodeling. Recently, a circulating
soluble form of LOX-1(sLOx-1), corresponding solely to its extracellular domain, has been identified
in human serum. Circulating levels of sLOX-1 are increased in inflammatory and atherosclerotic
conditions and are associated with acute coronary syndrome, with the severity of coronary artery
disease, and with serum biomarkers for oxidative stress and inflammation, suggesting that they
could be useful marker for vascular injury. Identification and regulation of this receptor and
understanding of signal transduction pathways might open new gateways from diagnosis to
therapeutics for cardiovascular diseases.
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Sheikh M S A, Yang T, Salma U, Ali M. The Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 and Cardiovascular Disease. Cardiovascular Journal. 2011; 3(2): 169-177.