Coronary Angiographic Patency in Patients With Acute Myocardial Infarction With or Without Thrombolytic Therapy.
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Date
2011
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Abstract
Background: The myocardial infarction (MI) is a leading cause of morbidity and mortality in
developed countries as well as in developing countries including Bangladesh. Streptokinase since
its introduction has been shown to reduce mortality significantly. The outcome of MI treated with
streptokinase can be evaluated either by CAG measurement of TIMI blood flow or by the measurement
of ST segment resolution in 12 lead ECG.
Methods: This cross sectional comparative study was conducted in the department of Cardiology in
Sylhet M A G Osmani Medical college, to compare the patency between MI patients with or without
streptokinase therapy, from Jan 2008 to Dec 2009. Considering enrollment criteria a total of 96
patients with acute MI were evaluated. All patients were categorized into two groups. Group-I
(n=48), who received streptokinase and Group-II (n=48), who did not received the same(due to late
presentation). CAG was done with in 7- 28 days of on set of pain. The patients admitting in coronary
care unit with the diagnosis of STEMI were taken as the study subjects.
Results: Adequate TIMI (thrombolysis in myocardial infarction) flow was higher who received
streptokinase (85.4%) than those who did not receive the therapy (52.1%).
Conclusion: This study indicates that streptokinase therapy is associated with rapid and sustained
reperfusion of the infarct related artery in the treatment of acute myocardial infarction.
Description
Keywords
Myocardial infarction, Thrombolytic therapy, Streptokinase, Coronary angiographic patency
Citation
Rahman M M, Dey S R, Shahabuddin M, Kundu A K, Rahman Z, Paul D, Chowdhury A R. Coronary Angiographic Patency in Patients With Acute Myocardial Infarction With or Without Thrombolytic Therapy. Cardiovascular Journal. 2011; 3(2): 136-142.