Effect of Polyherbal Formulation on Metabolic Derangements in Experimental Model of High Fructose Diet Induced Metabolic Syndrome.
Loading...
Date
2014-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
High fructose diet induces metabolic syndrome. Therefore an attempt has made to evaluate the effect
of Polyherbal formulation in male Wistar rats by oral administration of 350 mg/Kg body weight (HF1) and 500 mg/
Kg body weight (HF2). The clinical symptoms established in high fructose diet induced metabolic syndrome were
ameliorated by Poly herbal formulation. Food, water intake was increased in high fructose diet fed rats. Body weight,
abdominal waist and Body mass index were increased in only high fructose fed rats whereas reduced with poly herbal
formulation. Atherogenic index and Blood pressure were increased in only high fructose fed rats but reduced in rats
supplied with polyherbal formulation (HF1 and HF2) along high fructose. Biochemical components like fasting blood
glucose levels, triglycerides, total cholesterol, LDL, VLDL, SGOT, SGPT, Uric acid, Malondialdehyde (MDA) were
increased in only high fructose fed group rats whereas these components were reduced and normalised in groups of
rats fed with high fructose diet for 7 weeks in association with Herbal formulation HF1, HF2 for last three weeks
separately.HDL-C levels were found increased in rats even though supplied with polyherbal formulation.
Histopathology results of pancreas and liverof only high fructose fed rats indicated the infiltration of inflammatory
cells and fat accumulation which was ameliorated with HF1 and HF2.
Description
Keywords
High Fructose diet, Herbal formulation, Metabolic syndrome, Male Wistar rats
Citation
Thota Rohith N, Paruchuru Dilip, Naik R Ravindar, Metlakunta Anantha S, Benarjee G, Puchakayala Goverdhan. Effect of Polyherbal Formulation on Metabolic Derangements in Experimental Model of High Fructose Diet Induced Metabolic Syndrome. International Journal of Applied Biology and Pharmaceutical Technology. 2014 Jul-Sept; 5(3): 247-255.