Role of B Type Natriuretic Peptide in the Early Diagnosis of Left Ventricular Diastolic Dysfunction in High Risk Subjects.
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Date
2010
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Abstract
Background: Brain natriuretic peptide (BNP) reflects left ventricular pressure. It increases in
systolic dysfunction. Our aim was to evaluate role of plasma BNP level in early diagnosis of left
ventricular isolated diastolic dysfunction.
Methods: We studied 60 patients (male=18, female=42) with hypertension, diabetes mellitus, ischemic
heart disease, dyslipidemia. The Doppler parameters used for evaluation of diastolic dysfunction
are: isovolumetric relaxation time (IVRT), Transmitral flow velocities (E/A) ratio, deceleration
time (DT) & pulmonary vein Doppler findings. 49 patients (group-1) had diastolic dysfunction
whereas 11 patients (group-2) had normal flow patterns. Plasma BNP level was done in all patients.
Results: Mean plasma BNP levels were 40.41±6.82 pg/ml in individuals with normal filling patterns
and 183.36±25.28 pg/ml in subjects with abnormal diastolic dysfunction (p<0.001).The accuracy of
BNP in detecting diastolic dysfunction was assessed with receiver-operating characteristic(ROC)
analysis. The area under the ROC curve for BNP test accuracy in detection of any abnormal diastolic
dysfunction was 0.928 (95% CI, 0.861 to 0.994;p<0.001).A BNP value of 63 pg/ml had the sensitivity
of 89.9%,specificity of 91.9% and accuracy of 90.3%.PPVwas 97.8% and NPV-66.7% for detecting
diastolic dysfunction.
Conclusion: Raised plasma BNP level is useful for early diagnosis of isolated left ventricular
Diastolic dysfunction.
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Keywords
BNP, Diastolic dysfunction
Citation
Hoque S, Rahman M A, Haque M J, Khan A R, Rahman M S, Hoque M M, Hossain N. Role of B Type Natriuretic Peptide in the Early Diagnosis of Left Ventricular Diastolic Dysfunction in High Risk Subjects. Cardiovascular Journal. 2010; 3(1): 2-6.