Synthesis and Cell Line Activity of Angular Benzofuro Fused Naphthyridines.
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Date
2014-04
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Abstract
The present work describes the preparation of novel compounds based on the structure of 2-
substituted benzo[b]-furo[2,3-h][1,6]napthyridin-5[4H]-one (10). Their methyl and methoxy derivatives were
synthesized and their cytotoxicity evaluated against a cancer cell line HeLa. The analogue bearing methyl group on the
system is three times more potent than the methoxy group. One could suggest that the methyl group activates the
inhibitor’s site. These results provide new information on the structure activity relationship of these naphthyridine
based systems.
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Keywords
Naphthyridine, Cytotoxic activity, Benzo furo naphthyridine, 2-chloro-3-formyl quinoline
Citation
Murugesh Arumugam, Selvakumar A M Magesh, Rajendran Subramanian Parameswaran. Synthesis and Cell Line Activity of Angular Benzofuro Fused Naphthyridines. International Journal of Applied Biology and Pharmaceutical Technology. 2014 Apr-June; 5(2): 85-89.