Antioxidant and cytotoxic potential of methanol extract of Tabernaemontana divaricata leaves.
Loading...
Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The methanolic extract obtained from the leaves of Tabernaemontana divericata (Family: Apocynaceae) was evaluated for in vitro antioxidant potential by determination of total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test. The extract was also screened for its cytotoxic effect using brine shrimp lethality bioassay. The results revealed potent antioxidant property in all antioxidant assays compared to the reference antioxidant, ascorbic acid in a dose dependent manner. Further, the methanolic extract of Tabernaemontana divericata showed significant cytotoxic effect (LC50: 3.12μg/ml) compared with positive control, Vincristine Sulphate (LC50: 0.331μg/ml).
Description
Keywords
Tabernaemontana divaricata, Apocynaceae, Antioxidant, Cytotoxicity
Citation
Rumzhum Nowshin Nowaz, Rahman Mostafizur, Kazal Khalequzzaman. Antioxidant and cytotoxic potential of methanol extract of Tabernaemontana divaricata leaves. International Current Pharmaceutical Journal. 2012; 1(2): 27-31.