The evaluation of Serum Copper Level in Hemodialysis Patients with and without anemia Compared with Healthy Controls.
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Date
2015-01
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Abstract
ntroduction: Anemia is a common complication of ESRD with different etiologies. The most
common cause of anemia in such patients is insufficient production of erythropoietin by
kidneys. Another possible reason is copper deficiency, thus, this study is aimed to evaluate the
serum copper level among hemodialysis patients with and without anemia and to compare
them to healthy controls. Material and Methods: A total number of 56 patients who
underwent regular hemodialysis due to their ESRD were enrolled and divided into two groups
of 28 according to their Hgb results including patients with anemia (Hgb<11 gr/dl) and
patients without anemia (Hgb>11 gr/dl). Also, 28 healthy individuals participated as the
control group. Venous blood samples were collected from patients prior to hemodialysis.
Spectrophotometry employed for copper measurements. Data were analyzed using t-test and
Pearson regression analysis. Results: Mean age of patients was 44.36±15.80 years. No
significant difference was present among the three groups with regarding to age and gender.
Mean and SD of serum copper in patients with anemia, without anemia, and controls were
180.11±54.48, 139.66±35.57 and 155.82±42.06 μg/dl respectively. Serum copper level was
significantly higher in hemodialysis patients with anemia compared with those without anemia
(p<0.03). Also a significant inverse regression between serum copper and Hgb was present in
all hemodialysis patients (p=0.02, r=-0.37). Conclusion: Higher levels of serum copper in
anemic patients could be a result of restraining role of high serum copper on iron absorption
that has a negative effect on the production of Hgb. However, complementary studies are
required.
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Keywords
ESRD, anemia, serum copper, hemodialysis
Citation
Zeraati A, Sajad A A, Mahdi P S S, Farzaneh S, Reza H, Seifollah B M S. The evaluation of Serum Copper Level in Hemodialysis Patients with and without anemia Compared with Healthy Controls. Bangladesh Journal of Medical Science. 2015; 14(1): 43-48.