Cutaneous Leishmaniasis in El-Madinna Manowra region, Saudi Arabia in 2012.
Date
2013-07
Journal Title
Journal ISSN
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Abstract
Objective: Leishmaniasis is a parasitic disease causing major public health problem in form of visceral
and cutaneous types. The cutanoue leishmaniasis is caused by L. tropica, in low-land areas without reservoir;
Arthroponatic leishmaniasis (ACL), Zoonotic Cutaneous Leishmaniasis ( ZCL), in high-land. This
case report involved; 25 years old Egyptian active young single male adult, stayed in Utama (75 Km far
from El-Madina Manowra on the road to Makkah). He presented with three skin lesions on his arms
occurred within the last 1-3 months. on examination revealed; volcano- like indurated ulcers which clinically
suspected as leishmania lesions. Materials and Methods: Laboratory investigations were involved;
skin smear using Giemsa stain, Leishmanin test (LST), polymerase chain reaction (PCR), sequencing
and phylogenitic analysis BLAST (NCBI). Results: Microscopy positive LDB (leishmanin donovani
bodies), Leishmanin test (LST) was negative. PCR positive L. major. Sequence alignment were 100%
with nine Iranian isolates and one Tunisian isolate. After one month of treatment with Pentostam
(Sodium stibogluconate) local injections at the site of lesions the lesion progressed from ulcer to scar.
Conclusion: L. major is a major species causing cutaneous leishmaniasis in Al-Medina Manowra region
in Saudi Arabia. The usage of the polymerase chain reaction (PCR) is a useful diagnostic tool and help
to identify the causative species.
Description
Keywords
Cutaneous Leishmaniasis, L. tropica, L. (L) major, Skin lesion, Polymerase chain reactions
Citation
Abdalla N M, Abdelgani A M, Osman A A, Sarhan M A. Cutaneous Leishmaniasis in El-Madinna Manowra region, Saudi Arabia in 2012. Bangladesh Journal of Medical Science. 2013; 12(3): 325-330.