ABL Tyrosine Kinases and DNA Methylation May Mediate in High Glucose Induced Hyperosmolality; Role of Target Proteins.
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2013-10
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Abstract
Phosphorylation of proteins on their threonine, serine, and tyrosine residues is one of the most
commonly occurring posttranslational modifications in eukaryotic cells. Cellular phosphorylation cascades facilitates
the amplification of extracellular signals following changes in environmental conditions via the ability of
phosphorylated activators to modulate the expression of numerous genes. Because these reactions are rapidly
reversible, they are important for the regulation of many cellular functions including signal transduction, cell division,
and proliferation. Hyperosmolality can induce tyrosine phosphorylation of TonEBP/OREBP. Tyrosine
phosphorylation by Abl kinases of several target proteins is a key mechanism for modulating signal transduction in
hyperosmolar conditions. In this review article we discuss the role of Abl tyrosine kinases and DNA methylation
during glucose induced hyperosmolality.
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Tyagi Manoj G, Tyagi Vishakha. ABL Tyrosine Kinases and DNA Methylation May Mediate in High Glucose Induced Hyperosmolality; Role of Target Proteins. International Journal of Applied Biology and Pharmaceutical Technology. 2013 Oct-Dec; 4(4): 376-379.