Risk profile in asymptomatic first degree relatives of Coronary Artery Disease (CAD) patients.
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Date
2013-01
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Abstract
Aim: Cardiovascular disease is on the rise and is expected to be a leading cause of death and disability
worldwide. Identification of risk in asymptomatic individual in higher risk group could help to plan individual
patient’s management. Positive family history is one of the risk factors and screening at this level may
help in determining individual therapy. Studies have shown relation of positive family history but are lacking
in this part of world, so we considered it worthwhile to assess FRS in asymptomatic sibling of CAD
Patients Materials and methods: 75 volunteers were enrolled in the study and they underwent Bruce treadmill
exercise protocol after their initial evaluation, these volunteers than also underwent biochemical test –
Fasting blood sugar and lipid profile. These volunteers were divided into two groups based upon their
Treadmill test results. Results: 31 out of 75 volunteers were TMT positive and they were kept in one group.
These volunteers differed significantly (p<0.05) in higher age, fasting blood sugar and Low density lipoprotein
level (LDL). This group also had a significantly lower metabolic equivalents and higher Framingham
Risk Score. Conclusion: Our study showed that positive family history is associated with a higher
Framingham risk score in asymptomatic volunteers.
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Keywords
Coronary artery disease, Treadmill test, Framingham risk score, fasting blood sugar, lipid profile
Citation
Chawla O, Matreja P S, Pramod J. Risk profile in asymptomatic first degree relatives of Coronary Artery Disease (CAD) patients. Bangladesh Journal of Medical Science. 2013; 12(1): 67-73.