Utility of Biomarkers in Sepsis: Mirror Reflection of Inner Truculent Devil.
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Date
2013-01
Journal Title
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Abstract
There is a plethora of biomarkers proposed and being researched in the field of sepsis. The complex pathophysiology
of sepsis involves many mediators of inflammation pertaining to coagulation, complement, contact
system activation, inflammation, apoptosis, etc. Markers related to those processes can gauge the degree
of sepsis. Compared with localized pathology, the systemic nature and involvement of multiple organs in
sepsis gives scope for numerous potential biomarkers. There is no 'gold standard' for the diagnosis of sepsis.
Currently available/in-research biomarkers are compared for their efficacy with methods used to diagnose
and monitor sepsis such as combination of clinical signs and available laboratory variables. An arbitrary
classification of these biomarkers is made and the literature surrounding these markers and their efficacy
in diagnosis of sepsis is reviewed.
Description
Keywords
Sepsis, Inflammation, Biomarkers
Citation
Kota S K, Meher L K, Rao E S, Jammula S, Kota S K, Modi K D. Utility of Biomarkers in Sepsis: Mirror Reflection of Inner Truculent Devil. Bangladesh Journal of Medical Science. 2013; Jan-Mar: 12(1): 17-29.