Outcome of Tumor Lysis Syndrome with Hydration and Alkalinization in Children with Acute Lymphoblastic Leukemia.
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2012-10
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Abstract
Objective: To observe the out come of tumor lysis syndrome (TLS) following treatment with hydration and
alkalinization in children with acute lymphoblastic leukemia. Methodology: This is an observational study
which included 30 diagnosed ALL children who were at high risk of developing TLS in the Department of
Pediatric Hematology & Oncology, BSMMU, from January 2010 to July 2010. Result: The mean (±SD) age
was found 10.2±2.9 years and maximum (46.7%) numbers were found between 11 to 15 years. Male female
ratio was 2.3:1. High risk patients for developing TLS presented with huge organomegaly such as
hepatomegaly, splenomegaly, and lymphadenopathy associated with fever, anemia, and bony tenderness.
For diagnosis of Acute Lymphoblastic Leukemia (ALL) bone marrow study was done in all patients and
immunophenotyping in 40.0% patients. Hydration, Alkalinization, Tab Allopurinol and Oral Aluminum
hydroxide were used in all study patients while treatment. WBC and serum uric acid were found higher in
all patients during baseline investigation. After hydration and Alkalinization serum potassium, serum phosphate,
serum calcium and serum creatinine level were normal within 72 hours and serum uric acid within
day five. Mortality was found 6.7% and the cause of mortality was septicemia.
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Sultana A, Islam A, Akhtar G, Rahman M A. Outcome of Tumor Lysis Syndrome with Hydration and Alkalinization in Children with Acute Lymphoblastic Leukemia. Bangladesh Journal of Medical Science. 2012; 11(4): 284-291.