Comparison between Allopurinol and Febuxostat in management of gout patients - a prospective study.
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Date
2011
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Abstract
Aim:To assesses the efficacy of a relatively new drug-Febuxostat in management of gout and its comparison
with allopurinol. Method: A comparative study of both Allopurinol and Febuxostat was done on 100
patients of gout. Both were studied for efficacy. side effects and for gout flare up. Results: Primary efficacy
end point (baseline values) - a serum urate concentration of less than 6.0mg per deciliter at the last three
measurements was reached by 54 %( 27/50) of group A patients taking 80mgs of febuxostat and 25 %(
12/50) of group B patients taking allopurinol 300mgs per day (P<0.001) Secondary efficacy end point(follow
up values)- At first visit( after 2 weeks of onset of study), the proportions of subjects with serum urate
concentration of less than 6.0mg/dl was significantly higher in the group A receiving febuxostat than the
group B receiving allopurinol(P<0.001)[Tableno-1]. Conclusion: Febuxostat, at a daily dose was more
effective than allopurinol at the commonly used fixed daily dose of 300 mg in lowering serum urate. Results
of side effects and gout flare up were similar in both groups.
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Keywords
Allopurinol, febuxostat,, uric acid, gout
Citation
Singal K K, Goyal S, Gupta P, Aggawal B K. Comparison between Allopurinol and Febuxostat in management of gout patients - a prospective study. Bangladesh Journal of Medical Science. 2011; 10(4): 257-262.