Study of serum non-HDL cholesterol in cerebrovascular disease.
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Date
2010
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Abstract
Background: Non-HDL cholesterol is a potential newer risk factor for cerebrovascular
diseases (CVD). Objective: To explore the association of non-HDL cholesterol with
cerebrovascular disease. Methods: This case control study was carried out in the
Department of Biochemistry, BSMMU, Dhaka during the period of January to December
2007 to evaluate the association of non-HDL cholesterol with CVD in Bangladeshi
population. A total number of 135 subjects of both sexes were grouped as Group- (CVD
cases) and Group-II (Healthy controls). Group-I include 85 cases of which 59 were
ischaemic cerebrovascular diseases (ICVD) and 26 were haemorrhagic cerebrovascular
diseases (HCVD). By taking the history and doing clinical examination and laboratory
investigations, diabetes mellitus, malignant disease, renal disease, liver disease and
diuretic medication were excluded from study subjects. Serum non-HDL cholesterol was
measured in all study subjects. Statistical analysis was performed by using SPSS for
windows version 12.0. Mean values of the findings were compared between groups. One
way ANOVA test and multiple comparison (Bonferroni‘t’) test were used to see the level
of significance. Results: Serum non-HDL cholesterol found significantly increased in
CVD, ICVD and HCVD cases in comparison to control subjects. But ICVD and HCVD
cases did not differ with respect to serum non-HDLcholesterol. Conclusion: The result
shows that elevated non-HDL cholesterol is associated with CVD. Prospective study with
large sample size is required to evaluate the elevated Non-HDL cholesterol as a risk factor
of CVD.
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Keywords
Non-HDL cholesterol, Cerebrovascular disease, Ischaemic cerebrovascular, disease, Haemorrhagic cerebrovascular disease
Citation
Parvin S, Hoque M M, Sultana N, Naoshin Z. Study of serum non-HDL cholesterol in cerebrovascular disease. Bangladesh Journal of Medical Science. 2010; 9(3): 143-149.