Metabolic Syndrome in Hypothyroid Patients.
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Date
2014
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Abstract
Thyroid functions affect metabolic syndrome (MetS) parameters including blood pressure,
fasting plasma glucose, serum triglycerides and HDL-Cholesterol. But the relationship between
MetS and thyroid functions is yet to be identified clearly. Metabolic syndrome is a state in
which most features of hypothyroidism can be seen. The aim of the present study was to
investigate the frequency of MetS in hypothyroid patients. Thirty one patients with overt
hypothyroidism, 32 patients with subclinical hypothyroidism (SCH) and 58 euthyroid controls
were enrolled in this study. NCEP-ATP III criteria was used to diagnose metabolic syndrome.
Majority of the participants were in the age group of 30-40 years. Body mass index and waist
circumference, blood pressure, fasting plasma glucose and serum triglycerides were found to
be higher in hypothyroid patients compared to that of euthyroid controls (p<0.001). On the
other hand serum HDL-C was found to be significantly lower in hypothyroid patients compared
to that of euthyroid controls (p<0.001). Prevalence of MetS was 82.5% in the hypothyroid
group and 27.6% in eythyroid controls (p<0.001). No significant difference was found
between SCH (81.3%) and overt hypothyroid (86.7%) groups in respect to prevalence of MetS
(p<0.05). The findings of the study suggest a need to investigate the presence of
hypothyroidism during the management of MetS patients.
Description
Keywords
Overt hypothyroidism, Subclinical hypothyroidism, Metabolic syndrome, Lipid profile
Citation
Haque R, Ferdousi S, Ferdousi S S, Rahman W, Uddin M N, Hoque M M. Metabolic Syndrome in Hypothyroid Patients. Bangladesh Journal of Medical Biochemistry. 2014; 7(2): 57-61.