A Comparative Study on the Hepatoprotective Effect of Tamarindus indica and Vitamin E in Long Evans Rats.
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Date
2013
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Abstract
The protective effects of ethanolic extract of Tamarindus indica leaves and seeds in
compoarison to vitamin E, were studied on paracetamol induced hepatotoxicity in Long Evans
Rats. Different groups of animals were administered in the paracetamol (1500mg /kg, p.o.)
for 7 days. Ethanolic extracts of leaves and seeds of Tamarindus indica (1250mg/kg) with
parallel vitamin E (500 mg/kg), were administered to paracetamol pretreated rats. On
treatment with paracetamol a significant increase in alanine aminotransferase (ALT), aspartate
aminotransferase (AST), total bilirubin and alkaline phosphatase were observed. On
administration of ethanolic extracts of leaves and seeds a significant decrease in the level of
alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin and alkaline
phosphatase (ALP) were observed and histopathological examination of liver tissue revealed
an almost return to normal architecture. The result were almost comparable to vitamin E, a
known hepatoprotective agent.
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Keywords
Hepatoprotective agent, Tamarindus indica, Vitamin E
Citation
Shammi N J, Choudhry Z K, Khan MI, Hossain M M. A Comparative Study on the Hepatoprotective Effect of Tamarindus indica and Vitamin E in Long Evans Rats. Bangladesh Journal of Medical Biochemistry. 2013; 6(2): 63-67.