Comparison of Conventionally Measured Serum Bicarbonate Values with Bicarbonate Values Obtained in Arterial and Venous Blood Gas Analysis.
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Date
2012
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Abstract
Bicarbonate (HCO3-) measurement in serum or plasma from a sample of venous blood is
routinely practiced in hospital patient management. HCO3- status can also be assumed from
Blood gas analysis requiring arterial blood as sample which is cumbersome for both patients
and doctors. This study was undertaken to evaluate the extent of agreement among
biocarbonate values obtained during venous, arterial blood gas analysis and conventionally
measured serum bicarbonate levels in a group of intensive care unit (ICU) patients to
determine whether conventionally measured serum HCO3- (from peripheral venous blood)
and calculated HCO3-values (from arterial blood gas [ABG] analyzers) can be used
interchangeably. A total of 51 adult patients with diverse medical conditions, presenting at a
tertiary health centre ICU were enrolled in this study when deemed by the treating physician
to have an ABG analysis. Arterial and venous samples were taken as close in time as possible
for blood gas analysis and routine blood tests. Bland-Altman analyses were used to compare
the three methods. The HCO3- levels from ABG, Venous Blood gas (VBG) and
tconventionally measured serum HCO3- showed acceptably narrow 95% limits of agreement
using the Bland-Altman method. VBG reveals higher level of agreement with the ABG
bicarbonate values compared to measured serum HCO3-. Thus, venous blood can be an
alternate for arterial blood where ABG analyzer is available. conventionaly serum HCO3-
measurements can also be useful and used as substitute for an expensive ABG analyzer in
resource constrained health care sectors when required.
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Keywords
Arterial blood gas analysis, Venous blood gas analysis, Measured serum bicarbonate, Intensive Care Unit
Citation
Nargis W, Ahamed B U, Hossain Z, Zabeen S, Houqe N. Comparison of Conventionally Measured Serum Bicarbonate Values with Bicarbonate Values Obtained in Arterial and Venous Blood Gas Analysis. Bangladesh Journal of Medical Biochemistry. 2012; 5(1): 12-15.