Cardiac Troponin-I And CK-MB for Risk Stratification in Acute Myocardial Infarction (First Attack): A Comparative Study.
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Date
2011
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Abstract
Myocardial infarction is associated with release of two important enzymes. The enzymatic
diagnosis is mainly based on the measurement of CK-MB and troponin-I. Cardiac troponin-
I(cTnI) is known to have higher specificity and analytic sensitivity than CK-MB for detection
of myocardial injury & risk stratification. These are used both as diagnostic and prognostic
marker. This prospective observational study included 60 patients of 40-65 years age range,
diagnosed as acute myocardial infarction. The mean ages were 50± 8 years and 53±8 years
respectively. Male and female patients included were 86.7% and 13.3%; BMI was
25.3±1.5. The two important cardiac markers troponin-I and CK-MB were studied in 60
patients, admitted in the hospital with acute MI. Blood samples to estimate these markers
were collected from the patients after admission at 6-9 hours, 9-24 hours and after 24 hours
and their mean values with ±SD were calculated, evaluated and compared between the two
groups of patients with low and high risk MI. The patients with low risk MI were those who
recovered early and the high risk patients improved later in comparison to low risk group.
Out of 60 patients, 37 had troponin-I level>1.5 ng /ml. Among them 29 developed high risk
MI and 8 recovered earlier than high risk group. 23 patients had troponin-I <1.5 ng /ml, out
of whom 10 were high and 13 were low risk. The difference of troponin-I levels between
high and low risk groups of patients was statistically significant (p<0.01). On the other hand
CK-MB level was >7 ng /ml in 33 patients. Out of them 22 patients developed high and 11
patients were low risk but 18 patients out of 27 who had CK-MB <7 ng /ml became high
and 9 patients were low risk. The difference of outcome in respect to higher and lower
values of CK-MB between the two groups was not statistically significant (p>0.05). Both
troponin-I and CK-MB were estimated in all 60 patients on three occasions. The mean
troponin-I levels were statistically significant between the high and the low risk groups on
all occasions .On the contrary, the values of CK-MB were not statistically significant on two
occasions but was significant (p < 0.01) on one occasion when it was estimated at 9 - 24
hour. Serum cTnI is better and more characteristic biomarker than CK-MB for risk
prediction and prognosis evaluation in AMI patients.
Description
Keywords
Cardiac Troponin-I, CK-MB, Acute Myocardial Infarction, Risk Stratification
Citation
Joarder S, Hoque M, Towhiduzzaman M, Salehuddin AF, Islam N, Akter M, Kamal I M. Cardiac Troponin-I And CK-MB for Risk Stratification in Acute Myocardial Infarction (First Attack): A Comparative Study. Bangladesh Journal of Medical Biochemistry. 2011; 4(1): 10-15.