Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays.
Loading...
Date
2015-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O--glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O--glucoside showed the inhibitory activity in a dose-dependent manner and reach 44% of inhibition at 223.2 μM with 92% of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.
Description
Keywords
Sonneratia caseolaris, melanin biosynthesis, H2O2-scavenging, B16 melanoma cells, luteolin-7-O-ß-glucoside
Citation
Arung Enos Tangke, Kuspradini Harlinda, Kusuma Irawan Wijaya, Bang Tran Hai, Yamashita Shuntaro, Katakura Yoshinori, Shimizu Kuniyoshi. Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays. Journal of Applied Pharmaceutical Science. 2015 Oct; 5(10): 39-43.