Correlation between malondialdehyde (MDA) and uric acid levels in preeclampsia.
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Date
2015-06
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Abstract
Background: Hypertensive disorders of human pregnancy, such as preeclampsia, complicates a sizeable percentage
of all pregnancies, need its early indication and warning. The aim of present study was to determine the association
between lipid peroxidation product, serum malondialdehyde (MDA) and serum uric acid levels in preeclampsia and
find out any association between these two parameters in preeclampsia.
Methods: Thirty preeclampsia and thirty gestational age matched normotensive pregnant women attending Narayana
General Hospital, Nellore were included in the study. Serum MDA levels were measured by Thiobarbituric acid
reactive substances(TBARS) method and serum uric acid levels were estimated by automated chemistry analyser
using commercial kits.
Results: Serum MDA (Mean±SEM 24.4±2.38 vs 7.9± 0.28 nmol/ml, p value < 0.000) and serum uric acid levels (7.2
± 0.25 vs 3.9 ± 0.14 mg/dl, p value <0.000) were significantly elevated in preeclampsia cases when compared with
that of normotensive pregnant women. A weak positive correlation between serum uric acid and serum MDA (r value
0.065, p value 0.734) was noticed in preeclampsia.
Conclusion: Serum MDA and uric acid may be included as additional markers for screening and progression of
preeclampsia, thereby helpful in effectively treating the condition at an early stage.
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Keywords
MDA, Uric acid, Preeclampsia
Citation
Krishna T Sharmila, Rao E Venkata, Sowjanya B, Saseekala A, Naidu J N. Correlation between malondialdehyde (MDA) and uric acid levels in preeclampsia. International Journal of Research in Medical Sciences. 2015 June; 3(6): 1443-1445.