Application of Bromocresol Green and Bromothymol Blue for the Extractive Spectrophotometric Determination of Anti-hypertensive Drugs.
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Date
2015-07
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Abstract
Simple, selective and highly sensitive spectrophotometric methods are proposed for the rapid and accurate
determination of anti-hypertensive drugs namely telmisartan (TEL), propranolol (PRO), bisoprolol (BIS) and
carvedilol (CRV) in tablets and biological fluids using bromocressol green (BCG) and bromothymol blue (BTB).
The developed methods involve formation of stable yellow colored dichloromethane extractable ion-pair
complexes of the amino derivative of four antihypertensive drugs such as TEL, PRO, BIS and CRV with two
sulphonphthalein acid dyes, namely; BCG and BTB in acidic buffer. The effect of optimum conditions via pH on
the ion-pair formation, reagent concentration, time and temperature and solvent was studied. The composition of
the ion-pairs was found 1: 1 by Job’s method. The established methods having high sensitivity and good
selectivity could be applied to the determination of the studied drugs in pharmaceutical, urine and blood serum
samples with satisfactory results. The results obtained are good agreement with experimental data. The reaction
mechanism was also discussed.
Description
Keywords
Antihypertensive drugs, Extraction spectrophotometry, BCG and BTB dyes, Ion-pair complex, Pharmaceutical formulations
Citation
El-Didamony Akram M, Hafeez Sameh M, Saad Ahmed A. Application of Bromocresol Green and Bromothymol Blue for the Extractive Spectrophotometric Determination of Anti-hypertensive Drugs. Journal of Applied Pharmaceutical Science. 2015 July; 5(7): 122-129.