Virtual screening for potential COX-inhibiting constituents from Mimosa pudica.
Loading...
Date
2015-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Developing a new agent in the anti-inflammatory and analgesic field, plants secondary metabolites can be a good
source for the Non-Steroidal Anti-inflammatory Drugs (NSAID) drug development. For this purpose we
subjected the active compounds of Mimosa pudica Linn. to reveal its potentiality by molecular docking analysis
to find out its potent compound against COX which was done by GOLD docking analysis. Docking studies by
GOLD showed that vitexin of Mimosa pudica had the highest fitness score against the COX-1 which is 60.43 and
63.49 for COX-2 enzyme. Vitexin of Mimosa pudica detected with significant fitness score and hydrogen
bonding against COX-1 and COX-2 which may be a potent analgesic compound.
Description
Keywords
Mimosa pudica, Analgesic, Antiinflammatory, COX, Vitexin, Mimosine
Citation
Islam Ashekul, Kabir Mohammad Shah Hafez, Dash Raju, Emran Talha Bin, Uddin Md Zia, Nesa Khairun, Uddin Mir Muhammad Nasir, Ahsan Md Tanveer. Virtual screening for potential COX-inhibiting constituents from Mimosa pudica. Journal of Applied Pharmaceutical Science. 2015 July; 5(7): 71-75.