Comparative evaluation of short-term versus long-term post-operative antibiotic prophylaxis after mandibular fractures.
Loading...
Date
2015-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: No consensus is present among the clinicians regarding the use of
post-operative antibiotics after the open reduction and internal fixation. This study
evaluates the efficacy of short-term (48 hrs) versus long-term (5 days) post-operative
antibiotics in preventing infection rates after the open reduction and internal fixation
in mandible fractures.
Methods: A total of 80 patients of dentate mandibular fractures were divided
randomly in 2 groups; Group 1 received post-operative intravenous antibiotics
(amoxicillin+clavulanate 1.2 g+ metronidazole 0.5 g/100 cc) TDS for 48 hrs postoperatively
Group 2 received same course for 5 post-operative days and patient were
monitored for the signs of infection according to the centers for disease control and
prevention criteria, rise in white blood cells counts and C-reactive protein (CRP)
levels. Side effects were recorded in both groups.
Results: Out of 39 patients in Group 1 two patients showed rise in CRP levels and
single patient developed abscess, whereas in Group 2 wound dehiscence was noted
in 2 patients and both had prolonged rise in CRP levels at the 5th day.
Conclusions: No significant difference in post-operative infection rates was seen
between two groups which suggests short-term post-operative antibiotic treatment
is equally efficacious as long-term treatment.
Description
Keywords
Mandibular fractures, Post-operative infection, Post-operative antibiotic prophylaxis
Citation
Goel Mahesh, Kirti Shruti, Singh J, Tawar Rajiv, Kumar Arun. Comparative evaluation of short-term versus long-term post-operative antibiotic prophylaxis after mandibular fractures. International Journal of Basic & Clinical Pharmacology. 2015 Jul-Aug; 4(4): 761-764.