Anti-inflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation.
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Date
2015-07
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Abstract
Background: Side effects of anti-inflammatory agents are a major problem during
clinical use. The development of a newer, effective, and safe anti-inflammatory
agent should be considered. Boron-containing compounds are found effective as
anti-inflammatory agents with relatively low side effects. We aimed to evaluate the
anti-inflammatory activity of boron in animal models of chronic and granulomatous
inflammation.
Methods: Sixty-six Wistar rats were allocated into five groups; 1st (6 rats) treated
with vehicle only without induction as a negative control; 2nd (12 rats) allocated
into two subgroups, treated with vehicle only, with induction of chronic and
granulomatous inflammation, as appositive control. 3rd group (24 rats) allocated
into four subgroups, treated with different doses of boron (3 and 6 mg/kg) in both
models. Fourth group (12 rats) treated with dexamethasone (1 mg/kg) in the same
models. 5th group (12 rats used) treated with boron (3 mg/kg) with dexamethasone
(1 mg/kg) in the same models.
Results: Boron, in a dose-dependent pattern significantly decreases inflammation
in rat models of chronic and granulomatous inflammation. Combination of boron
with dexamethasone significantly suppresses inflammation in both models, which is
significantly higher than all of the effects produced by other approaches of treatment.
Conclusion: Boron, in a dose-dependent pattern, effectively suppresses
formaldehyde-induced chronic inflammation and cotton pellet-induced granuloma
in rats when used alone or as an adjuvant with dexamethasone. It may be considered
as a potential treatment for chronic inflammatory conditions.
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Keywords
Boron, Chronic inflammation, Granuloma, Rats
Citation
Ameen Hanaw N Mohammed, Hussain Saad Abdulrahman, Ahmed Zheen A, Aziz Tavga A. Anti-inflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation. International Journal of Basic & Clinical Pharmacology. 2015 Jul-Aug; 4(4): 701-707.