Influence of Micronutrient Status during Infancy and Middle Childhood on Cognition at Middle Childhood.
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Date
2015
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Abstract
Objectives: To evaluate the relationship between micronutrient status during infancy and middle
childhood on cognition at middle childhood.
Methods: A longitudinal study was conducted in apparent healthy children in the northeast of
Thailand. Intelligence Quotient (IQ) was measured using the Wechsler Intelligence Scale for
Children, III (Thai) at 9 y. Hemoglobin, serum ferritin, and serum zinc (sZn) were assessed at early
infancy (4 mo), late infancy (1 y), and middle childhood (9 y). Serum transferrin receptor and urine
iodine (UI) were assessed at 9 y. Using multiple regression, the relationship between micronutrient
status during infancy and middle childhood and cognition at middle childhood was ascertained.
Results: Full scale IQ and performance IQ at 9 y was influenced by sZn at 1 y (β = 0.4 μmol/L, p =
0.011 and β = 0.6 μmol/L, p = 0.001). The influence of UI at 9 y on Verbal IQ at 9 was small but
significant (β = 0.02 μg/L, p = 0.024). None of the iron status at 4 mo, 1 y, and 9 y were associated
with IQ.
Conclusions: In apparent healthy children, zinc status at late infancy and iodine status at middle
childhood were associated with IQ at middle childhood. Further analyses are needed to understand
this relationship.
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Pongcharoen Tippawan, Chitchumroonchokchai Chureeporn, Yamborisut Uruwan, Boonpraderm Atitada, Wasanwisut Emorn, Winichagoon Pattanee. Influence of Micronutrient Status during Infancy and Middle Childhood on Cognition at Middle Childhood. European Journal of Nutrition & Food Safety. 2015 Special issue; 5(5): 757.