A review of the drug pregabalin.
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Date
2015-07
Journal Title
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Abstract
Pregabalin (PGB) is a well-established anticonvulsant and analgesic agent. The
stydy reviewed the mechanism of action, pharmacokinetics, adverse drug reactions,
contraindications, and various uses of PGB. Literature search was done to identify
the relevant studies. PGB is an antagonist of voltage-gated calcium channels and
specifically binds to α2-δ subunit to produce antiepileptic and analgesic activity. It
has less protein binding activity and lacks hepatic metabolism. It is unlikely to cause
pharmacokinetic drug-drug interactions. It has a wide safety margin and does not
require serum drug monitoring. The above-mentioned favorable pharmacological
benefits of PGB makes it a first-line or adjunctive therapy in various conditions
like diabetic peripheral neuropathy, post-herpetic neuralgia, in partial seizures and
generalized anxiety disorders.
Description
Keywords
Pregabalin, Neuropathic pain, Partial seizures, Efficacy, Safety
Citation
Manjushree N, Chakraborty Ananya, Shashidhar K, Narayanaswamy Srinivas. A review of the drug pregabalin. International Journal of Basic & Clinical Pharmacology. 2015 Jul-Aug; 4(4): 601-605.