To study the comparative effects of nebivolol and metoprolol on lipid profile in patients of essential hypertension.
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Date
2015-05
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Abstract
Background: Hypertension and certain alteration in serum lipoproteins are
complementary coronary risk factors. The effect of antihypertensive agents on
lipid metabolism exhibits a wide range. Numerous studies have established that
vasodilating beta-blockers are associated with more favorable effects on glucose
and lipid profiles than non-vasodilating beta-blockers. The study was conducted to
study the comparative effects of nebivolol and metoprolol on lipid profile in patients
of essential hypertension.
Methods: A prospective, randomized open label single center study was conducted
in the Department of Pharmacology in collaboration with Department of Medicine,
MGM’s Medical College and Hospital, Aurangabad in newly diagnosed patients of
essential hypertension. Sixty patients of either sex in the age group of 30-65 years with
blood pressure (BP) of ≥140/90 mmHg with deranged lipid parameters according to
National Cholesterol Education Program were randomized into two groups. Group I
received metoprolol (50 mg) and Group II received nebivolol (5 mg), both given
once daily for 12 weeks. BP and lipid parameters were evaluated at baseline as well
as at the end of 12 weeks.
Results: There was significant reduction in BP values (p<0.0001) as compared
to baseline in both the groups, however no significant difference was observed
between two drugs revealing that their efficacy in reducing systolic BP/diastolic BP
is comparable. Furthermore, both the drugs had a favorable effect on lipid profile,
but more significant results on lipid profile were observed in the nebivolol group as
compared to metoprolol group (p<0.0001).
Conclusions: In our comparison study, it is seen that the favorable effect of nebivolol
on serum lipids and its good tolerability profile make it a good choice for control
of hypertension as well as preventing the long-term cardiovascular morbidities and
mortalities.
Description
Keywords
Essential hypertension, Beta-blocker, Metoprolol, Nebivolol, Lipid profile
Citation
Johar Sukhmeen Kaur, Bhosle Deepak, Jaybhaye Deepali, Sheikh Alimuddin. To study the comparative effects of nebivolol and metoprolol on lipid profile in patients of essential hypertension. International Journal of Basic & Clinical Pharmacology. 2015 May-Jun; 4(3): 574-578.