Evaluation of antidepressant and analgesic activity of tapentadol with mirtazapine: an experimental study.
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Date
2015-05
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Abstract
Background: Data comparing tapentadol with an antidepressant is limited.
A comparison of tapentadol with mirtazapine at different dose has not been performed,
the other antidepressant in the same therapeutic class with a significant market share,
has been undertaken. In the absence of relevant data to assess the place that tapentadol
should occupy in the therapeutic arsenal, indirect comparisons are the most rigorous
way to go. We conducted a study evaluate antidepressant and analgesic activity of
tapentadol with mirtazapine at different doses in Swiss albino mice.
Methods: Tapentadol was administered at 10, 20 and 40 mg/kg (i.p) once daily for
14 days to swiss albino mice of either sex. The immobility period for antidepressant
activity of mice were recorded in forced swim test and reaction time for analgesic
activity of mice were recorded in tail flick test of the control and drug treated group.
The antidepressant and analgesic activity of tapentadol (10, 20, 40 mg/kg i.p) was
compared with that of mirtazapine (3, 5, 7 mg/kg i.p), administered for 14 days.
Results: Tapentadol produced better antidepressant at (20, 40 mg/kg), but less at
10 mg/kg and significant analgesic activity at all the three doses, as indicated by
reduction in immobility times and increase in reaction time as compared to control.
Mirtazapine produced no antinociceptive activity at 3 mg/kg, but significant at 5,
7 mg/kg and showed better antidepressant activity at all the three doses in mice.
The result of this study indicates the better analgesic activity of tapentadol at all
the doses and least antidepressant activity at 10 mg/kg, as compared to mirtazapine
which has shown better antidepressant activity at all the three doses but no analgesic
activity at 3 mg/kg.
Conclusion: It can be concluded that tapentadol is a better drug in case of depression
associated with pain compared to mirtazapine in mice.
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Keywords
Antidepressant, Analgesic, Tail flick test, Forced swim test
Citation
Chaudhary Pankaj K, Jain Atul, Pathak Asha, Sharma Neha, Mishra Atul K, Maurya Arvind K, Gaur Vikas. Evaluation of antidepressant and analgesic activity of tapentadol with mirtazapine: an experimental study. International Journal of Basic & Clinical Pharmacology. 2015 May-June; 4(3): 414-418.