A quasi-experimental study to assess the effect of a local anesthetic proparacaine on tropicamide-induced pupillary dilation.
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Date
2015-03
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Abstract
Background: Dilating the pupil is one of the most commonly practiced methods
among ophthalmologists to examine the eye especially the posterior segment of the
eye. Here we conducted a study to know the clinical effect of proparacaine, a local
anesthetic, on tropicamide-induced pupillary dilation.
Methods: A Quasi-experimental study was conducted on 57 subjects aged between 20
and 70 years. Study was done over a period of 3 months (February 14 - April 14) at a
tertiary health care center in Bagalkot after obtaining institutional ethical committee
clearance. Proparacaine was instilled in one eye (right eye) before instilling
tropicamide and the other eye with a placebo (normal saline). Pupil diameter was
measured using a pupillary gauge at 0, 15, and 30 mins. Results were analyzed using
unpaired Student’s t-test.
Results: The mean clinically efficient pupillary diameter at the end of 15 mins in
proparacaine instilled eye was 5.56±0.5 and in control eye was 5.25±0.45 mm with
t value 8.13 (p<0.001) which was statistically significant. And at the end of 30 mins
pupillary diameter in the study group was 7.96±0.43 mm and in the control group was
7.83±0.43 mm with t value of 4.115 (p<0.001) which was also statistically significant.
Conclusions: Therefore, we do recommend the use of proparacaine before instilling
tropicamide for faster pupillary dilation.
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Keywords
Proparacaine, Pupillary dilation, Tropicamide, Clinically effective diameter
Citation
Menishinkai Jayashree Padmaraj, Pujar Chaitra, Manasa C N, Dasar Laxman V, Salagar Mallikarjun C. A quasi-experimental study to assess the effect of a local anesthetic proparacaine on tropicamide-induced pupillary dilation. International Journal of Basic & Clinical Pharmacology. 2015 May-June; 4(3): 410-413.