Evaluation of anti-infl ammatory activity of ethanolic extract of Cananga odorata Lam in experimental animals.
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Date
2015-03
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Abstract
Background: The current study evaluates the anti-infl ammatory activity of ethanolic
extract of Cananga odorata Lam (EECO) in experimental animals.
Methods: Acute toxicity test was done following OECD guidelines. Carrageenan
induced paw edema method in Wistar Albino rats were used in this study. Aspirin
in the dose of 300 mg/kg was used as the standard drug and three doses of EECO
(100 mg/kg, 200 mg/kg and 400 mg/kg b.w. p.o) were used as the test drug. The
results were measured at 1st hr, 3rd hr and 5th hr after carrageenan injection.
Results: EECO in the doses of 100 mg/kg, 200 mg/kg and 400 mg/kg showed highly
signifi cant anti-infl ammatory activity (p<0.001) (p<0.001) (p<0.001) at 3rd hr and
(p<0.001) (p<0.001) (p<0.001) 5th hr, respectively. In doses of 100 mg/kg, 200 mg/kg,
and 400 mg/kg of EECO showed the percentage of inhibition of 62.9% which is more
than the standard drug aspirin, which showed 60.14% inhibition.
Conclusion: EECO has signifi cant anti-infl ammatory activity.
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Keywords
Ethanolic extract, Cananga odorata Lam, Anti-infl ammatory activity
Citation
Maniyar Yasmeen A, Devi C H Janaki. Evaluation of anti-infl ammatory activity of ethanolic extract of Cananga odorata Lam in experimental animals. International Journal of Basic & Clinical Pharmacology. 2015 Mar-Apr; 4(2): 354-357.