To investigate the role of Memantine as anxiolytic in elevated plus maze test and as antidepressant in tail suspension test in Swiss albino mice.
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Date
2015-03
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Abstract
Background: The magnitude of improvement seen with present conventional
medicines for anxiety and depression remain disappointing thereby providing a scope
for the study of newer drugs. In the literature, there is evidence demonstrating the
modulation of N-methyl-D-aspartate (NMDA)receptors in anxiety and depression.
The present study is undertaken to evaluate the antianxiety effect of memantine in
elevated plus maze (EPZ) test and its antidepressant effect in tail suspension test
(TST)in Swiss albino mice.
Methods: Animals were divided into six groups (n=6). First group mice were given
normal saline (10 ml/kg), second group were administered lorazepam (0.5 mg/kg),
third group with memantine (3 mg/kg) and fourth group with memantine plus
lorazepam, fi fth group was administered amitriptyline (10 mg/kg)and sixth group
received memantine plus amitriptyline. All drugs were administered by intraperitoneal
route daily for 7 consecutive days. Results were analyzed by one-way ANOVA
followed by post-hoc Tukey’s test.
Results: Memantine treated mice showed signifi cant increase (p<0.001)in time
spent and number of entries in open arm and signifi cant decrease in time spent and
number of entries in closed arm in EPZ when compared to control group. Duration
of immobility was signifi cantly (p<0.001)reduced in animals treated with memantine
when compared to the control group in TST.
Conclusions: NMDA antagonist, memantine has showed signifi cant antianxiety
effect in EPZ test and antidepressant effect in TST.
Description
Keywords
Memantine, N-methyl-D-aspartate-antagonist, Elevated plus maze test, Antianxiety, Tail suspension test, Antidepressant
Citation
Bagewadi Harish G, Venkatadri T V, Rajeshwari B. To investigate the role of Memantine as anxiolytic in elevated plus maze test and as antidepressant in tail suspension test in Swiss albino mice. International Journal of Basic & Clinical Pharmacology. 2015 Mar-Apr; 4(2): 213-218.