Prescribing pattern of antipsychotic medications in patients with schizophrenia in a tertiary care hospital.
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Date
2015-01
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Abstract
Background: The objective of thisstudy was to study the prescribing pattern of
antipsychotic medications in patients with schizophrenia in a tertiary care hospital.
Methods: An observational study was conducted in psychiatry outpatient
department (OPD) of Bapuji and Chigateri hospital attached to Jagadguru Jayadeva
Murugarajendra medical college, Davangere. The data collected, had information
about age, gender, education, occupation, marital status and drug prescription that
included trade name, generic name, dosage and frequency of administration of 100
outpatients who attended the psychiatry OPD.
Results: A total of 100 prescriptions were analyzed of which 6% was monotherapy,
where Asenapine was the only drug used and rest 94% was combination therapy.
About 94% of the combination therapy included the use of single antipsychotic
with anticholinergic drug and multiple antipsychotics with anticholinergic drug.
A combination of multiple antipsychotics with anticholinergic was most commonly
used, that is trifluoperazine and chlorpromazine (36%), followed by trifluoperazine
and risperidone (13%), trifluoperazine and quetiapine (8%), risperidone and
quetiapine (7%), trifluoperazine, chlorpromazine along with quetiapine (3%).
Among single antipsychotic with anticholinergic, risperidone (20%) was most
commonly used, followed by Trifluoperazine (7%). Use of the anticholinergic drug,
Trihexyphenidyl accounts to 94% of the total prescriptions.
Conclusions: Schizophrenia is mostly seen in males, middle age group and
unemployed people. The present study showed that combination therapy is
preferred for the treatment of Schizophrenia. Despite several side-effects, typical
antipsychotics, especially trifluoperazine was the most commonly used drug, followed
by chlorpromazine either alone or in combination. Among atypical antipsychotics,
risperidone was commonly used followed by quetiapine and asenapine. Most of the
patients received trihexyphenidyl, an anticholinergic drug along with antipsychotics
to reduce extra pyramidal side-effects.
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Keywords
Atypical antipsychotics, Prescribing pattern, Schizophrenia
Citation
Sushma H K, Jyothi C H, Somashekar H S, Avanthi E, Imran M, Raja Babool. Prescribing pattern of antipsychotic medications in patients with schizophrenia in a tertiary care hospital. International Journal of Basic & Clinical Pharmacology. 2015 Jan-Feb; 4(1): 134-138.