A comparative study of efficacy and safety of pitavastatin versus atorvastatin in the patients of dyslipidemia in medicine department of a tertiary care teaching hospital.
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Date
2015-01
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Abstract
Background: Cardiovascular diseases (CVDs) are the major cause of death globally.
Dyslipidemia is one of the most significant risk factors for CVD. 3-hydroxy 3-methyl
glutaryl coenzyme A reductase inhibitors (statins), which are used for the treatment
of dyslipidemia, has a beneficial effect in both primary and secondary prevention of
CVD. Hence, this study was done to compare the efficacy and safety of atorvastatin
versus pitavastatin in patients of dyslipidemias.
Methods: After obtaining ethical clearance from institution and written informed
consent from patients, 100 patients included in the study were randomly allocated
to any of the following two groups. (1) Group A: Tablet atorvastatin 10 mg given
orally once a day for 12 weeks. (2) Group B: Tablet pitavastatin 2 mg given orally
once a day for 12 weeks. The primary endpoint of the study was a comparative
assessment of change in lipid profile (triglyceride, low-density lipoprotein [LDL],
high-density lipoprotein [HDL]) from baseline and after 12 weeks. The secondary
endpoint involved recording all the adverse effects during the study.
Results: Analysis of the baseline and post 12 weeks lipid levels by non-parametric
unpaired t-test showed a statistically significant increase in HDL-cholesterol (HDL-C)
in Group B as compared to Group A (p=0.028 i.e. p<0.05). However, there was no
significant difference between two groups in decreasing LDL-cholesterol (LDL-C)
(p=0.615).
Conclusions: In this study, pitavastatin is found to be more efficacious than
atorvastatin in increasing HDL-C levels, while as efficacious as atorvastatin in
decreasing LDL-C in dyslipidemic patients. Atorvastatin is better tolerated than
pitavastatin.
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Keywords
Dyslipidemia, Atorvastatin, Pitavastatin
Citation
Vasani Punita, Savsani Durgesh, Mehta Dimple, Bhatt Preeti, Solanki Sandip. A comparative study of efficacy and safety of pitavastatin versus atorvastatin in the patients of dyslipidemia in medicine department of a tertiary care teaching hospital. International Journal of Basic & Clinical Pharmacology. 2015 Jan-Feb; 4(1): 24-29.