Maternal Thyroid Function and Birth Outcomes after Iodine Supplementation in Mild-to-moderately Iodine-deficient Pregnant Women in Thailand.
Loading...
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objectives: To evaluate the effects of iodine supplementation in mild-to-moderately iodinedeficient
pregnant Thai women on maternal thyroid function and birth outcomes.
Methods: An RCT with 200 μg KI per day was conducted among 514 mild-to-moderately iodinedeficient
pregnant Thai women. Blood samples were collected at baseline (<14 weeks of
gestation), and follow up samples were collected in the 2nd, and 3rd trimester and at delivery in cord
blood. Free T4 (fT4), thyroglobulin (TG) and thyroid-stimulating hormone (TSH) concentration were
measured. Neonatal data was obtained from hospital records. Thyroid volume of the newborns
was measured using ultrasonography. Data were analyzed per protocol by linear mixed models
and linear regression models.
Results: Cumulative loss to follow up was 20% in the 2nd trimester, 23% in the 3rd trimester, and
28% at delivery. Median maternal fT4, TG and TSH concentration did not differ significantly
between treatment groups (p>0.05). Mean birth weight was 3150±410 g in the iodine group as
compared to 3088±473 g in the placebo group (p>0.05); 4.8% of infants in the iodine group were
low birth weight versus 7.9% in the placebo group. There were no significant differences in median fT4, TG and TSH concentration, and mean thyroid volume of the newborns between treatment
groups (p>0.05).
Conclusions: Maternal iodine supplementation normalized iodine status and resulted in lower
maternal TSH concentrations during pregnancy. Further data analysis should reveal whether
iodine supplementation has led to any improvement in child development in this population.
Description
Keywords
Citation
Gowachirapant Sueppong, Melse-Boonstra Alida, Winichagoon Pattanee, Pornkul Ratanaporn, Zimmermann Michael. Maternal Thyroid Function and Birth Outcomes after Iodine Supplementation in Mild-to-moderately Iodine-deficient Pregnant Women in Thailand. European Journal of Nutrition & Food Safety. 2015 Special issue; 5(5): 672-673.