Prevalance and antimicrobial susceptibility pattern of clinical isolates of pseudomonas aeruginosa in a Tertiary Care Teaching Hospital.
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Date
2013-07
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Abstract
The study was conducted to know the prevalence of Pseudomonas aeruginosa in clinical infections
and its antibiotic susceptibility pattern to commonly used antibiotics in a tertiary care teaching hospital. We received
897 relevant clinical isolates among, which 203 was P.aeruginosa. Antibiotic susceptibility was determined by Kirby
Bauer’s disc diffusion method with first line and second line antibiotics. Results – Among the first line antibiotics
the isolate displayed an increased resistance to Ciprofloxacin (28.57%) followed by Levofloxacin (25.61%), and the
least was towards Amikacin (14.77%), whereas most of the second line antibiotics such as Polymyxin B and Colistin
exhibited a high sensitivity (99.02 %.). Conclusion-The ability of the opportunistic pathogen P.aeruginosa to rapidly
develop resistance to multiple classes of antibiotics during the course of treatment makes it important to determine
the antibiotic susceptibility pattern. As the pipeline of new drugs continues to diminish, it is critical that we look for
new strategies to combat the threat of antibacterial resistance.
Description
Keywords
Drug resistance, P. aeruginosa
Citation
Agarwal Saloni, Rai Rekha, Karnaker Vimal, Sanjeev H, Pai Asha K B, Ganesh H R. Prevalance and antimicrobial susceptibility pattern of clinical isolates of pseudomonas aeruginosa in a Tertiary Care Teaching Hospital. International Journal of Applied Biology and Pharmaceutical Technology. 2013 Jul-Sept; 4(3): 251-254.