Antimicrobial Activity of Phenylpropanoyle from the Rhizome of Zingiber officinale Roscoe (Zingiberaceae).
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Date
2014-02
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Abstract
Aim: This study was carried out to determine the phytochemical and the antimicrobial
activities of Zingiber officinale (Zingiberaceae) Rhizome. Methodology: The air-dried and powdered rhizome (1.0 kg) of Z. officinale was extracted
with ethyl acetate (1.5 L) at room temperature for 72 h. After evaporation under reduced
pressure, 46.5 g of crude extract was obtained. The CH2Cl2 extract was purified by
column chromatography over silica gel 60 (230-400 mesh) and preparative TLC using a
gradient system of hexane, ethyl acetate and MeOH.
Agar diffusion test plates with Escherichia coli CIP 548, Listeria monocytogenes CIP
82110, Enterococcus faecalis CIP 76117, Bacillus cereus CIP 6624, Staphylococcus
aureus CIP 7625, Pseudomonas fluorescents CIP 6913, Bacillus substilis ATCC 6636,
Candida lusitaniae ATCC 200950, Candida tropicalis ATCC 750, Cryptococcus
neoformans CIP 95026, Aspergillus flavus, and Aspergillus parasiticus as test strains
were performed.
Results: A new nonyl-3-phenylpropanoate (1), together with known compounds, 8-
hepthyl-12- propyldecanol (2) were isolated from the ethyl acetate extract of the rhizome
of Zingiber officinale. The structures of the two compounds were determined by
comprehensive analyses of their 1D and 2D NMR, mass spectral data, chemical
reactions, and comparison with previously known analogue.
The two compounds isolated from ethyl acetate extract showed antibacterial and
antifungal activity and the Minimal Inhibitory Concentration (MIC) against the test fungi
varied from 3.34 mM to 5.08 mM for compound 1 and from 3.81 mM to 5.08 mM for
compound 2.
Conclusion: One new compound, nonyl-3-phenylpropanoate, isolated from ethyl acetate
extract of Zingiber officinale rhizome exhibited antibacterial and antifungal activities.
Description
Keywords
Zingiber officinale, Zingiberaceae, Phenylpropanoyle, Antimicrobial activity
Citation
Emmanuel Talla, Aristide Bealem, Leopold Tatsadjieu Ngoune, BenoƮt Ngassoum Martin, Duplex Wansi Jean, Gbaveng Yaya, Bernard Dabole, Alain Meli, Joseph Mbafor Tanyi, Roch Alain. Antimicrobial Activity of Phenylpropanoyle from the Rhizome of Zingiber officinale Roscoe (Zingiberaceae). European Journal of Medicinal Plants. 2014 Feb; 4(2): 126-134.