Antimicrobial activity of extracellular metabolite of endophytic fungi Phomopsis spp. Isolated From Four Different Medicinal Plants of India.
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Date
2013-04
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Abstract
The present investigation is on endophytic fungus Phomopsis spp isolated from four Indian medicinal
plants like., Artabotrys odoratissimus, Cassia auriculata, Guazuma ulmifolia and Terminalia catappa in four different
months. Antimicrobial activity of ethyl acetate extract from the culture filtrate of Phomopsis spp were tested against
six human pathogenic bacteria. Isolated three Phomopsis spp. were grown in Czapex Dox Broth for 21-days. The
extracellular secondary metabolites present in the culture filtrate were extracted with ethyl acetate solvent. The
extracellular bio-active compounds of the isolated fungus were tested for its anti microbial potential in well diffusion
method, against three, Gram-positive and Gram-negative bacteria such as Staphylococcus aureus, Bacillus subtilis,
Micrococcus luteus, Escherichia coli, Klebsiella Pneumoniae and Pseudomonas aeruginosa. Among all the three
Phomopsis spp, the extract obtained from Phomopsis sp.2 exhibited a promising activity against the entire test
bacteria. This bioactivity compounds focus on clinical pharmacology to identify a novel therapeutic targets and it can
be easily scaled up for the large-scale commercial production.
Description
Keywords
Phomopsis spp, Bioactive compounds, Antibacterial activity, Medicinal Plants, Ethyl acetate extract
Citation
Gopinath K, Senthilkumar V, Arumugam A, Kumaresan S. Antimicrobial activity of extracellular metabolite of endophytic fungi Phomopsis spp. Isolated From Four Different Medicinal Plants of India. International Journal of Applied Biology and Pharmaceutical Technology. 2013 Apr-June; 4(2): 40-46.