Cardioprotective and Antilipidemic Effect of Gemmotherapeutically Treated Glycyrrhiza glabra against Isoproterenol Induced Myocardial Injury.
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Date
2013-07
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Abstract
Aims: To evaluate preventive (pre- treated) and curative (post treated) potential of
gemmomodified and native extract of Glycyrrhiza glabra for alleviating harmful changes in
lipid profile (HDL, LDL, TG, TC) and cardiac enzymes (CK-MB, LDH, SGOT, SGPT)
against isoproterenol (ISO) induced myocardial injury in rabbits.
Study Design: In vivo study.
Place and Duration of Study: Department of Chemistry and Biochemistry, University of
Agriculture, Faisalabad, Pakistan, between February 2011 and April 2011.
Methodology: Thirty six rabbits weighing 1.25 ± 0.2 Kg were allocated into six groups
(Control, Ischemia, Gemmo curative, Native curative, Gemmo preventive and Native
preventive) having six animals each. Rabbits were fed normal diet for 20 days. Gemmo
preventive and Native preventive groups were also given gemmo modified and native
extract (100 mg kg-1). On 20th day and 21st day rabbits were given ISO (50 mg kg-1). Five
days after the ischemia the Gemmo curative and Native curative groups were given
gemmo and native extracts (100 mg kg-1). Serum activities of lipid profile and cardiac
enzymes were determined. Results: ISO administration significantly lowered (P=.05) HDL level and increased
(P=.05) LDL, TG and TC as compared with control rabbits. ISO injury significantly
increased (P=.05) the levels of cardiac enzymes CK-MB. LDH, SGOT and SGPT as
compared with control rabbits. Curative treatment with gemmo and native extracts of
Glycyrrhiza glabra significantly increased (P=.05) level of HDL and lowered (P=.05) the
level of LDL, TG, TC and cardiac enzymes as compared with ischemic rabbits. Pre
treatment with gemmo and native extracts prevented the reduction (P=.05) in HDL level
and resisted the rise (P=.05) in other lipid parameters and cardiac enzymes as after ISO
induced myocardial injury. Pretreatment with extracts was significantly better (P=.05) than
curative treatment. Gemmo extract was significantly better (P=.05) than native extract in
preventive and curative treatment in normalizing serum levels of lipid parameters and
cardiac enzymes in ISO injured rabbits.
Conclusion: The results provide evidence for the first time that gemmo extract of
Glycyrrhiza glabra prevents myocardial injury induced by ISO in rabbits.
Description
Keywords
Glycyrrhiza glabra, isoproterenol, lipid profile, cardiac enzymes
Citation
Hamid Mohsina, Khalil-ur-Rehman, Jahan Nazish. Cardioprotective and Antilipidemic Effect of Gemmotherapeutically Treated Glycyrrhiza glabra against Isoproterenol Induced Myocardial Injury. European Journal of Medicinal Plants. 2013 Jul-Sept; 3(3): 405-421.