Phytochemical screening and insilico approach for the identification of anti stress compounds from medicinal plants.
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Date
2013-01
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Abstract
In India, many forms of alternative medicines are available for those who cannot be helped by
conventional medicine. Ayurvedha and Herbal medicine are two important forms of alternative medicine that is
widely available in India. This work was mainly concerned with the identification of the therapeutic properties of
Indian medicinal plant extracts. Everyone knows that medicinal plants have disease curing properties and this is due
to the compounds presents in the extracts used for the treatment. So we identified the compounds of different
medicinal plants like Celastrus paniculatus, Withania somnifera, Convolvulus pluricaulis, Rauvoifia Serpentina etc
which are used as medicine for Stress in Ayurvedha from previous literature. After identification using chemsketch
software these compounds were designed and screened for antistress property. The proteins responsible for stress in
Homo sapiens were collected using Protein databank (PDB). Active sites were identified and used for docking with
the compounds. Then the compounds were docked to the Calcium channel in order find better inhibitor. Among 33
compounds 10 compounds showed best docking results for each protein. ADMET studies were performed using
Molinspiration and OSIRIS server.
Description
Keywords
Anti stress, Docking, ADME studies, Calcium Channels
Citation
Rayalu D Jayasimha, Muralidhararao D, Rao D S. Phytochemical screening and insilico approach for the identification of anti stress compounds from medicinal plants. International Journal of Applied Biology and Pharmaceutical Technology. 2013 Jan-Mar; 4(1): 324-334.