Design and development of levofloxacin hemihydrate fast dissolving tablets using fenugreek powder.
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Date
2012-10
Journal Title
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Abstract
Levofloxacin hemihydrate is an antibiotic used for bacterial infections. It belongs to flouroquinolones
class. Fast dissolving tablets gaining popularity over conventional tablets due to their convenience in administration
and suitability for patients like geriatrics and pediatric patients because of their swallowing difficulties. The half-life
of the drug is 6-8 hrs and it is rapidly and completely absorbed after oral use for that levofloxacin prepared as fast
dissolving tablets. Tablets were prepared by direct compression technique by using MCC as binder. Super
disintegrants used are SSG(2%,3%,4% and 5%),CCS(AC-DI-SOL) (2%,3%,4%and 5%), CP(2%,3%,4%and5%)and
FGP(2%,3%,4%and 5%),.Among these 4 super disintegrants, Fenugreek powder (FGP) was show best results in the
evaluation tests.
Description
Keywords
Fast dissolving tablets, Levofloxacin hemihydrate, direct compression technique, super disintegrants
Citation
Chakravarthi B Naveen, Rao N Narasimha, Babu P Srinivasa. Design and development of levofloxacin hemihydrate fast dissolving tablets using fenugreek powder. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Oct-Dec; 3(4): 87-95.