PLGA/PLA microparticulate system: A boon for hydrophobic drug delivery.
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Date
2012-07
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Abstract
Controlling In-vitro drug release profiles for a system of PLGA/PLA microparticles
encapsulating a hydrophobic drug. Challenges with the diversity of drug properties, microencapsulation
methods, are evaluated with a focus on decreasing the time to lab-scale encapsulation of water-insoluble
drug candidates in the drug development stage. The development of biodegradable microparticles systems
that combined the beneficial properties of polymeric microparticles for hydrophobic drug delivery were
reviewed here. Injectable biodegradable and biocompatible copolymers of lactic and glycolic acid are
important advanced delivery system for week too month controlled release of hydrophobic drug (e.g., from
biopharmaceutical classification system class IV), which often display poor oral bioavailability. Finally, three
important properties affecting release behavior were identified as: polymer hydrophobicity, particle size and
particle coating, . This review focuses on the microencapsulation of hydrophobic drugs, describes a variety
of techniques for their preparation and analytics.
Description
Keywords
Controlled release microparticles, drug release mechanism, drug delivery, PLGA end groups, Microencapsulation, hydrophobic drug
Citation
Thakor Namita M, Varde Neha M, Sini Surendran C, Shah Viral H, Upadhyay U M. PLGA/PLA microparticulate system: A boon for hydrophobic drug delivery. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Jul-Sept; 3(3): 121-132.