Effect of ethanolic extract of plectranthus amboinicus leaf on healing of burn wound in wistar rats.
Loading...
Date
2012-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objectives: To study the effect of ethanolic extract of the leaf of Plectranthus amboinicus
on the healing of burn wounds in wistar rats and compare it with silver sulfadiazine treated group.Materials
and Methods: Five groups of rats were used in the study. Partial thickness burn wounds were made on
each rat under ketamine anesthesia.The wounds in the five groups of rats were treated topically with
petroleum base, silver sulfadiazine,1%, 2% and 3% ointment of ethanolic extract of Plectranthus
amboinicus, respectively, once daily for 21 days or till complete healing whichever was earlier. The wound
contraction rate and period of epithelization were monitored. Results: The rate of wound contraction was
significantly more in Plectranthusamboinicustreated groups in comparison to the control. The mean period
of epithelization was significantly decreased in Plectranthus amboinicus treated group when compared to
control (P < 0.01) and silver sulfadiazine (P =0.02) treated group. Conclusion: The ethanolic extract of
Plectranthusamboinicuspromoted healing of burn wound in wistar rats.
Description
Keywords
Plectranthusamboinicus, burn wound, epithelization, wound contraction, healing
Citation
Shenoy Smita, Sukesh, Vinod M S, Shruthi, Amberkar Mohan, Amuthan Arul. Effect of ethanolic extract of plectranthus amboinicus leaf on healing of burn wound in wistar rats. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Jul-Sept; 3(3): 32-35.