The steroidal component and hypoglycaemic effect of stem bark extract of mitragyna inermis (wild) O. Kundze (rubiaceae) in alloxan induced diabetic wistar rats.
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Date
2012-04
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Abstract
Among other ethno medicinal uses, Mitragyna inermis have been claimed by traditional medical
practitioners in northern Nigeria to be an effective anti-diabetic agent. The hypoglycaemic effect of the ethanol
extract of M. inermis on blood glucose levels of alloxan induced diabetic albino rats have been investigated. The
results revealed that the plant possessed hypoglycaemic activity. Doses of 250, 350 and 450mgkg-1 body weight
intraperitoneally (i.p.) were administered to the rats but the 350mg/kg-1 dose exhibited the highest hypoglycaemic
potentials. The LD50 value (1600mgkg-1) recorded on the ethanol extract of stem-bark of M. inermis indicated that
it is slightly toxic but could be used safe on human at lower doses. Silica gel column fractionation of the ethanol
extract of M. inermis led to the isolation of a pure compound 1, 5-cholesten-3-phenyl-22, 24-β-diketone. 1H and
13C NMR and IR spectroscopy have been used jointly to determine the conformation of the compound.
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Keywords
Steroids, Stem bark, Mitragyna inermis
Citation
Adoum O A, Nenge H P, Chedi Bashir. The steroidal component and hypoglycaemic effect of stem bark extract of mitragyna inermis (wild) O. Kundze (rubiaceae) in alloxan induced diabetic wistar rats. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Apr-Jun; 3(2): 169-174.