Spectral and electrochemical studies of fluvoxamine.
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Date
2012-01
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Abstract
The spectral and voltammetric behavior of fluvoxamine (1) in aqueous buffers
of varied pH is presented. Spectrophotometry, cyclic voltammetry, differential pulse
polarography and coulometry were utilized to study its proton and electron transfer
characteristics. Relevant thermodynamic and electrochemical data such as charge transfer coefficient
(αna), heterogeneous forward rate constant (k0
f,h), etc, have been evaluated. An
excellent electroanalytical assaying of 1 has been developed in differential pulse polarography
at pH = 3. Molecular modeling on various acid-base conjugates of 1 and their several
conformers has been carried out to arrive at the thermodynamic and conformational issues to
correlate to the spectral and electrochemical observations.
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Keywords
Fluvoxamine, acid-base equilibria, cyclic voltammetry, molecular modeling
Citation
Vijaybhaskar P, Ramachandraiah A. Spectral and electrochemical studies of fluvoxamine. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Jan-Mar; 3(1): 239-245.