Assessment of insulin resistance and lipid bound sialic acid in alcoholic liver disease.
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Date
2012-01
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Abstract
Background: Even though alcoholic liver disease is common disease in India, there are only limited
reports about insulin resistance and no reports about lipid bound sialic acid in these cases. The present
study was designed to evaluate insulin resistance and lipid bound sialic acid levels in patients with
alcoholic liver disease
Materials and methods: 50 alcohol liver disease cases groups [Fatty liver (n=18), alcoholic hepatitis
(n=19) and cirrhosis (n=13)] and 38 controls were enrolled in the study. Fasting insulin, lipid bound sialic
acid and liver function test parameters were analyzed in both the groups
Results: Insulin, homeostasis model of insulin resistance and lipid bound sialic acid were significantly
increased in alcohol liver disease cases compared to controls. Both insulin and insulin resistance were
higher in alcoholic hepatitis and cirrhosis group compared to fatty liver group and controls
Conclusion: To conclude, the present study demonstrates increased insulin resistance and lipid bound
sialic acid in patients with ALD.
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Keywords
Alcohol liver disease, insulin resistance, lipid bound sialic acid
Citation
Selvakumar C, Sridhar M G. Assessment of insulin resistance and lipid bound sialic acid in alcoholic liver disease. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Jan-Mar; 3(1): 100-104.